immunosequencing identifies signatures of cytomegalovirus exposure history and hla-mediated effects on the t cell repertoire.
2017-07-13
ryan emerson and colleagues report immunosequencing of the variable region of the tcr[beta] chain in 666 individuals with known cytomegalovirus (cmv) status. they show that cmv status and hla genotype shape the t cell repertoire and demonstrate proof of principle that tcr[beta] sequencing can be used as a specific diagnostic of pathogen exposure.
